作者：
Khatib, Hasan;Townsend, Jessica;Konkel, Melissa A.;Conidi, Gabi;Hasselkus, Julia A.
通讯作者：
Khatib, H
作者机构：
Univ Wisconsin, Dept Anim & Dairy Sci, Madison, WI USA.
Univ Wisconsin Madison, Dept Anim & Dairy Sci, 1675 Observ Dr, Madison, WI 53706 USA.
通讯机构：
Univ Wisconsin Madison, Dept Anim & Dairy Sci, 1675 Observ Dr, Madison, WI 53706 USA.
语种：
英文
关键词：
Transgenerational epigenetic inheritance,epigenetic reprogramming,acquired trait,environmental epigenetics
期刊：
Epigenetics
ISSN：
1559-2294
年：
2024
卷：
19
期：
1
页码：
2333586
基金类别：
Agriculture and Food Research Initiative Competitive from the USDA National Institute of Food and Agriculture [2023-67015-39527
摘要：
While transgenerational epigenetic inheritance has been extensively documented in plants, nematodes, and fruit flies, its existence in mammals remains controversial. Several factors have contributed to this debate, including the lack of a clear distinction between intergenerational and transgenerational epigenetic inheritance (TEI), the inconsistency of some studies, the potential confounding effects of in-utero vs. epigenetic factors, and, most importantly, the biological challenge of epigenetic reprogramming. Two waves of epigenetic reprogramming occur: in the primordial germ cells and the developing embryo after fertilization, characterized by global erasure of DNA met...
